Increased uptake of indium-111 pentetreotide up to 10 years after external thoracic irradiation: report of two cases
Identifieur interne : 000048 ( Main/Exploration ); précédent : 000047; suivant : 000049Increased uptake of indium-111 pentetreotide up to 10 years after external thoracic irradiation: report of two cases
Auteurs : RBID : ISTEX:259_1996_Article_BF00834537.pdfEnglish descriptors
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Abstract
Indium-111 pentetreotide scintigraphy was performed in two patients for the localization of recurrent medullary thyroid carcinoma treated by surgery and external radiotherapy 1 and 10 years earlier. A marked uptake of the radiopharmaceutical was demonstrated in the lung areas that had been irradiated. These cases strongly suggest that this uptake is related to pulmonary fibrosis, a well-known complication of radiotherapy, even long after the irradiation. Therefore, attention must be paid to the avoidance of false-positive interpretation of somatostatin receptor scintigraphy in patients previously treated by radiotherapy.
DOI: 10.1007/BF00834537
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<author><name>Michel Stoffel</name>
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<author><name>François Jamar</name>
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<author><name>Julian Donckier</name>
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<author><name>Philippe Hainaut</name>
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<author><name>Patrick Decoster</name>
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<author><name>Christian Beckers</name>
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<author><name>Stanislas Pauwels</name>
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<front><div type="abstract" xml:lang="eng">Indium-111 pentetreotide scintigraphy was performed in two patients for the localization of recurrent medullary thyroid carcinoma treated by surgery and external radiotherapy 1 and 10 years earlier. A marked uptake of the radiopharmaceutical was demonstrated in the lung areas that had been irradiated. These cases strongly suggest that this uptake is related to pulmonary fibrosis, a well-known complication of radiotherapy, even long after the irradiation. Therefore, attention must be paid to the avoidance of false-positive interpretation of somatostatin receptor scintigraphy in patients previously treated by radiotherapy.</div>
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<abstract lang="eng">Indium-111 pentetreotide scintigraphy was performed in two patients for the localization of recurrent medullary thyroid carcinoma treated by surgery and external radiotherapy 1 and 10 years earlier. A marked uptake of the radiopharmaceutical was demonstrated in the lung areas that had been irradiated. These cases strongly suggest that this uptake is related to pulmonary fibrosis, a well-known complication of radiotherapy, even long after the irradiation. Therefore, attention must be paid to the avoidance of false-positive interpretation of somatostatin receptor scintigraphy in patients previously treated by radiotherapy.</abstract>
<subject lang="eng"><genre>Key words</genre>
<topic>Medullary thyroid carcinoma</topic>
<topic>Somatostatin receptor scintigraphy</topic>
<topic>Indium-111 pentetreotide</topic>
<topic>Radiotherapy</topic>
<topic>Radiation fibrosis</topic>
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<topic>Imaging / Radiology</topic>
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<identifier type="issn">0340-6997</identifier>
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